Human Sera
Cayman Chemical NIlvadIpIn 100mg
An L-type calcium channel blocker; selective for L-type over N-, P/Q-, and R-type calcium channels at 10 μM; inhibits increases in systolic blood pressure induced by chronic intravenous infusion of endothelin in rats at 10 mg/kg per day, p.o.; decreases cortical and hippocampal amyloid-β burden in the APPsw (Tg2576) and PS1/APPsw transgenic mouse models of Alzheimer’s disease at 0.03% (w/w) in the diet for 17 and 10 months, respectively; reduces infarct volume in a rat model of MCAO-induced focal cerebral ischemia at 3.2 mg/kg, s.c.
Cayman Chemical MefloquInhydrochlorIde 50mg
An antimalarial compound; increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively; inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites; A2A receptor antagonist; 5-HT2A and 5-HT2C agonist; has various effects on calcium homeostasis; has effects in mice typically associated with anxiolytic and antidepressant-like behavior
Cayman Chemical SuramInsodIum salt 100mg
A polysulfonated naphthylurea with antiviral, antiparasitic, and anticancer activities; is negatively charged at physiological pH therefore exhibiting polypharmacology; reduces Zika virus infectivity in Vero cells (IC50 = ~2.5-5 UG/ml); induces cell cycle arrest at the G2/M phase and apoptosis in L. donovani promastigotes in vitro and reduces hepatic parasitic burden in a mouse model of L. donovani-induced visceral leishmaniasis; reduces tumor volume in PDX mouse models of malignant mesothelioma at 60 mg/kg
Cayman Chemical Lusutrombopag 50mg
A thrombopoietin receptor agonist; induces proliferation of Ba/F3 cells expressing human MPL (EC50 = 84 nM) but not of those expressing mouse Mpl; increases the number of circulating platelets in a transgenic mouse model expressing human MPL at 0.3-10 mg/kg per day and increases the number of megakaryocytes in the bone marrow at 10 mg/kg per day
Cayman Chemical NDesethylamIodaronhydroch 50mg
the major CYP3A4 metabolite of amiodarone; used as an analytical reference standard for monitoring clinical efficacy of amiodarone in plasma samples
Cayman Chemical DerythroLthreo Lysosphngo 50mg
A mixture of the bioactive sphingolipids D-erythro and L-threo lysosphingomyelin
Cayman Chemical MInaprInhydrochlorIde 100mg
An antidepressant; reduces immobility time in the forced swim test in rats at 5 mg/kg for nine days; induces convulsions in rats at 40 mg/kg
Cayman Chemical SemaglutIdesodIum salt 100mg
A GLP-1R agonist (EC50 = 6.2 pM in a reporter assay using BHK cells expressing the human receptor); decreases blood glucose levels in the db/db mouse model of type 2 diabetes (ED50 = <2 nmol/kg); prevents decreases in the number of dopaminergic neurons in the substantia nigra and increases in lipid peroxidation in the substantia nigra and striatum, as well as improves motor coordination in the rotarod and footprint tests in a mouse model of Parkinson’s disease induced by MPTP at 25 nmol/kg; decreases neuronal loss in the hippocampal dentate gyrus and CA1 and CA3 regions and improves motor coordination and grip strength in the beam-walking and hanging wire tests, respectively, in a rat model of stroke induced by permanent MCAO at 10 nmol/kg every other day
Cayman Chemical R4AmIno3hydroxybutyrIc 50mg
A GABA receptor modulator; binds to GABAA and GABAB receptors (IC50s = 1 and 0.35 µM, respectively); inhibits GABA uptake in rat brain synaptosomes (IC50 = 67 µM); induces currents in a patch-clamp assay using Xenopus oocytes expressing human GABAC (EC50 = 19 µM); inhibits electrical discharges in the amygdala in a cat model of N-amidinobenzamide-induced seizures at 20 mg/animal
Cayman Chemical RosIglItazon 100mg
A PPARγ agonist; activates PPARγ1 and PPARγ2 in reporter assays (EC50s = 30 and 100 nM, respectively); selectively activates chimeras containing the LBDs of PPARγ over PPARα and PPARδ in a cell-based reporter assay at 10 mM; an inhibitor of ACSL4 (IC50 = 0.5 µM), inhibits RSL3-induced ferroptosis in Pfa1 cells and Pparg KO cells, and increases survival in a Gpx4 KO mouse model of ferroptosis at 0.0125 mg/ml in the drinking water; decreases HbA1c and fasting blood glucose levels in a rat model of type 2 diabetes induced by STZ and a high-carbohydrate and high-fat diet at 4 mg/kg
Cayman Chemical N-BenzylpalmItamIde 50mg
A long-chain fatty acid amide isolated from the maca plant that moderately inhibits FAAH activity (44% inhibition at 500 µM); many members of this family demonstrate selective antiproliferative activity against diverse cancer cell lines
Cayman Chemical LCL-161phenol 100mg
A derivative of LCL-161 and a PROTAC synthetic intermediate; has been used in the synthesis of PROTACs that drive degradation of androgen receptors
Sigma Aldrich Fine Chemicals Biosciences IgA from human serum reage5MG
IgA from human serum reage5MG
Cayman Chemical RaltItrexed 50mg
An inhibitor of thymidylate synthase (Ki = 62 nM); inhibits the growth of L1210 mouse lymphocytic leukemia cells in vitro (IC50 = 8 nM); reduces thymidylate synthase activity and completely eliminates tumors in a mouse L1210:ICR ascitic tumor model at 4 mg/kg; reduces tumor growth and the number of metastases in an HCT116-luc mouse xenograft model